South Carolina at Ole Miss Picks and Predictions for Saturday, November 1, 2025

By: David Anicetti Published 11/01/2025, 12:00 AM ET

On Saturday, South Carolina (3–5, 1–5 SEC) visits No. 8 Ole Miss (7–1, 4–1 SEC) at Vaught-Hemingway Stadium in Oxford. The starting kickoff has not been announced yet. The Gamecocks lost 29–22 to Alabama last Saturday, while the Rebels beat Oklahoma 34–26 on Saturday. Score the winning touchdown with our free college football picks.

South Carolina Gamecocks Preview

South Carolina is averaging 22 points per game and moving the ball mostly through the air. Quarterback LaNorris Sellers has thrown for 1,134 yards, 5 touchdowns, and 2 interceptions while completing 65% of his passes. Vandrevius Jacobs leads the receivers with 343 yards and 2 touchdowns, and Nyck Harbor has 278 yards on 17 catches. The run game has struggled, averaging only 3.0 yards per carry. Rahsul Faison leads the group with 281 yards and 3 touchdowns.

The Gamecocks’ defense has held up better than their record suggests. Linebacker Bryan Thomas Jr. leads the team with 4 sacks, and Peyton Williams has 2 interceptions. Opponents have controlled the clock and found success on third down against the Gamecocks. South Carolina will need three-and-outs from its defense and sustained drives by the offense.

Ole Miss Rebels Preview

Ole Miss averages 34 points per game and has been balanced on offense. Quarterback Trinidad Chambliss has thrown for 1,549 yards, 8 touchdowns, and only 1 interception while completing 63% of his passes. Running back Kewan Lacy has been steady with 618 yards and 10 touchdowns on 138 carries. Harrison Wallace III leads the receivers with 400 yards, and tight end Dae’Quan Wright has 393 yards and 3 touchdowns.

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The Rebels’ defense is giving up just under 20 points per game. Linebacker TJ Dottery leads the team with 46 tackles, while linemen Will Echoles and Zxavian Harris have 3 sacks each. Ole Miss has been strong at the line of scrimmage, holding opponents under 4.0 yards per carry in conference play.

South Carolina at Ole Miss Prediction

Ole Miss has more firepower and a much stronger running game. South Carolina has competed but continues to struggle against top SEC offenses. The Rebels will control the game on both sides of the line of scrimmage from start to finish. Final Score Prediction: Ole Miss Rebels win and cover ATS, 34–14.