South Carolina vs. LSU Picks and Prediction For Saturday October 11, 2025

By: Dylan Hellebrand Updated 10/10/2025, 10:42 PM ET

On Saturday, the South Carolina Gamecocks (3-2) face off against the LSU Tigers (4-1) at Tiger Stadium in Baton Rouge, Louisiana. The game will be aired on SEC Network. Discover which teams the pros are backing with our daily college football picks.

Game Information for South Carolina vs LSU

October 11, 2025, 7:45pm EST
Tiger Stadium
SEC Network
81° sunny/cloudy at start time

LSU Form & Recent Results

LSU heads into this matchup hoping to shake off a recent 24-19 loss to Ole Miss, which snapped their four-game win streak to start the season. Despite the setback, the Tigers have shown some real promise, especially on offense. Quarterback Garrett Nussmeier has been a focal point, completing 21 of 34 passes in the game against Ole Miss, throwing for a touchdown and an interception. So far this season, he’s racked up 1,159 passing yards, helping to drive the Tigers’ attack. On the ground, Caden Durham has amassed 213 rushing yards, giving LSU some needed balance to their offense. As for the passing game, Aaron Anderson leads the receiving corps with 305 yards, while Barion Brown isn’t too far behind with 239 yards, providing Nussmeier with plenty of reliable targets. Through their first five games, LSU has been putting up an average of 27 points per game, slightly down from last season’s average of 29.3, but still enough to keep them competitive each week. After their narrow defeat, the Tigers are eager to get back on track, and they’ll be counting on the energy of their home crowd to push them to a much-needed win over South Carolina.

South Carolina Form & Recent Results

South Carolina comes into this matchup riding the momentum of a recent victory, having won three out of their first five games this season. The Gamecocks’ most impressive showing so far was a 35-13 triumph over Kentucky two weeks ago, where quarterback LaNorris Sellers put together an efficient performance, completing 11 of his 14 passes. So far this year, Sellers has racked up 886 passing yards, showing consistent improvement with each game. In the backfield, Rahsul Faison has contributed 163 rushing yards, helping to keep opposing defenses honest. On the receiving end, Vandrevious Jacobs has emerged as a primary target, tallying 323 receiving yards, with Nyck Harbor also making a strong impact with 220 receiving yards. Offensively, South Carolina has been averaging 24.8 points per game over their first five games, as they aim to hand LSU their second straight defeat. For comparison, last season the Gamecocks averaged 28.3 points per contest, so they’re still searching for that explosive offensive form as the season progresses.

Key Players For South Carolina and LSU

South Carolina QB LaNorris Sellers: 58/87, 4 TD, 1 INT
LSU QB Garrett Nissmeier: 115/171, 7 TD, 3 INT

Betting Odds & Market Overview:

LSU -9.5; O/U 44.5

South Carolina vs LSU Picks and Prediction

LSU is hoping to bounce back and steer clear of a second straight defeat as they welcome South Carolina to Baton Rouge. The Tigers will be eager to put their last loss behind them and regain some momentum in front of their home crowd. Meanwhile, South Carolina has struggled to find their footing this season, but they’ll be determined to turn things around. The Gamecocks are aiming to avoid picking up their third loss and would love to pull off a statement victory on the road. Final Score Prediction, LSU Tigers win and cover the spread, 30-19.

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