South Carolina vs Missouri Picks and Prediction for Saturday September 20 2025

By: Eddie Kline Updated 09/19/2025, 03:38 PM ET

SEC Conference foes will square off on Saturday night in a high stakes South Carolina vs Missouri tilt.

See below for our top South Carolina vs Missouri picks and make sure to follow along all season with our college football picks.

South Carolina Preview

The Gamecocks (2-1) finished last year on a tear, but have lost plenty of talent from that squad. South Carolina currently ranks last in the SEC Conference in total offense and is scoring 23 points per game.

On Saturday, South Carolina failed to score during the final 55 minutes of a 31-7 home loss versus Vanderbilt. RB Rahsul Faison scored the only touchdown for the Gamecocks and finished with a game-high 74 rushing yards. South Carolina committed eight penalties for 85 yards and turned the ball over four times.

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Missouri Preview

The Missouri Tigers are off to a hot start and have a really good chance of being 5-0 when they host Alabama in a few weeks. The Tigers (3-0) lead the SEC Conference in total offense and are scoring 51.7 points per contest. Last week, Missouri erupted for 38 points during the first half and cruised to a 52-10 home victory versus Louisiana.

Ahmad Hardy ripped through the Louisiana defense with 250 rushing yards on 22 carries and found the end zone three times. Missouri QB Beau Pribula completed 15 of 22 passes for 174 yards and two touchdowns. The Tigers limited the Ragin’ Cajuns to four passing yards on 14 attempts.

South Carolina vs Missouri Pick

South Carolina QB LaNorris Sellers was forced to exit Saturday’s loss with a head injury and his status for this game is uncertain. The Gamecocks have struggled on offense and have benefitted from a couple of special team scores. With Sellers likely sidelined, look for Missouri to win at home in a game that stays under the total. Final Score Prediction, Missouri Tigers win 27-14.

The Pick: Missouri -9.5