Southern Miss vs Louisiana Picks and Prediction for Saturday, October 18, 2025

By: Cameron Ross Updated 10/17/2025, 09:11 PM ET

Southern Miss vs Louisiana information

The Southern Miss Golden Eagles stay on the road this week with the game at Cajun Field at 5:00 PM against the Louisiana Ragin' Cajuns. Southern Miss has four wins and two losses on the year, having won four of the last five, including two in a row after a narrow 3-point road victory against Georgia Southern. The Louisiana Ragin' Cajuns return home this week two games below .500 through 6 games played, having dropped three of the last four after a 10-point loss to James Madison last week on the road. Stay in the action with our College Football Picks.

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Southern Miss Preview

Offensively, Southern Miss has carried their own this season, averaging 32.1 points per game overall. Defensively, the Golden Eagles have been mediocre, allowing 27.6 points per game this season. Braylon Braxton leads the Southern Miss offense this season with 1473 yards and 13 scores on 128 completions. Jeffrey Pittman is the top ball carrier with 346 yards and six touchdowns on 74 carries. Carl Chester has been the main target in the Southern Miss offense with 267 yards and two scores on 16 catches.

Louisiana Preview

Louisiana has struggled on the defensive side of the ball this season, allowing 30.8 points per game overall. Offensively, Louisiana has had just as many issues, averaging just 25.8 points per game this season. Daniel Beale leads the Louisiana offense this season with 395 yards and one score on 42 completions. Lunch Winfield has completed 23 passes for 372 yards and four scores. Zylan Perry has been a focus for the Louisiana offense with 59 carries for 411 yards and five touchdowns. Robert Williams leads the team with 233 yards on 14 catches.

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Southern Miss vs Louisiana Prediction

Southern Miss is playing the better football coming into this matchup and will continue that trend against Louisiana. The Golden Eagles are better on both sides of the ball and will overwhelm Louisiana start to finish. Take Southern Miss to extend their winning streak this week with a win and cover on the road. Final Score Prediction, Southern Miss Golden Eagles win and cover 42-31