St. Francis vs Buffalo Picks and Prediction for Saturday, September 6, 2025

By: Cameron Ross Published 09/02/2025, 11:45 PM ET

St. Francis Preview

The Saint Francis Red Flash stay on the road this week with the game up north in Buffalo against the Buffalo Bulls. Saint Francis is winless on the year following a 29-point loss to ULM in week one of the year. The Saint Francis offense was stagnant in week 1, scoring no points on 131 total yards after turning the ball over once in the game. Defensively, the Red Flash were outmatched, giving up 29 points, including 19 in the second half, on 434 total yards of offense. Stay in the action with our College Football Picks.

Nick Whitefield Jr. led the way for the Saint Francis offense in week 1, completing 9 passes for 36 yards. Jeff Hoenstine completed three passes for 14 yards in the game. Raph Ekechi led the way on the ground with 37 yards on 10 carries. Zachary Betts led the team with two catches for 16 yards.

Buffalo Preview

The Buffalo Bulls will be at home for the first time this season this week, winless on the year following a 13-point loss on the road to Minnesota to open the season. Offensively, Buffalo struggled, scoring just 10 points on 151 total yards after converting just one of 11 on 3rd down. Defensively, Buffalo was outmatched, giving up 23 points on 443 total yards.

Ta’Quan Roberson led the charge for the Buffalo offense in week 1, completing 12 passes for 107 yards and one score, and running the ball 9 times for seven yards. Al-Jay Henderson was the top ball carrier with 25 yards on 11 carries. Victor Snow led the team with 67 yards and one score on five receptions in week one. Jasaiah Gathings chipped in as well for the Buffalo offense with 21 yards on three receptions.

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St. Francis vs Buffalo Pick

Despite being winless, Buffalo was the better team in this matchup and will right their wrongs from a week ago. Look for Buffalo to use their strengths on both sides of the ball to overwhelm a bad Saint Francis team. Take the Bulls this week to get their first win of the season as they get the cover at home against Saint Francis. Final Score Prediction, Buffalo Bulls win and cover 35-13.