Syracuse vs Notre Dame Picks and Predictions for Saturday, November 22, 2025

By: Cameron Ross Updated 11/22/2025, 01:14 AM ET

Syracuse vs Notre Dame Information

The Syracuse Orange will be on the road this week with the game inside Notre Dame Stadium at 3:30 PM against the Notre Dame Fighting Irish. Syracuse has just three wins through 10 games played this season, riding a long losing streak following a 28-point road loss. loss against Miami in their last outing. The Notre Dame Fighting Irish are the number 9-ranked team in the nation with eight wins and two losses on the year, riding a long winning streak after a 22-point road victory against Pittsburgh in their last game. Don’t bet blind—our free college football predictions show you where the value is.

Syracuse Preview

Steve Angeli leads the Syracuse offense this season with 1317 yards and 10 touchdowns on 98 completions. Ricky Collins has added 1042 yards and six scores on 97 completions to go along with 126 yards and one touchdown on 54 carries. Yasin Willis is the top ball carrier on the team with 558 yards and four scores on 129 carries, while Will Nixon has added 77 carries for 326 yards and three scores. The best sportsbooks are the best way to go when you are betting on Syracuse.

Notre Dame Preview

CJ Carr leads the Notre Dame offense this season with 2407 yards, 21 touchdowns, and 173 carries. Jeremiyah Love is the top ball carrier for Notre Dame this season, with 1135 yards and 14 touchdowns on 177 carries. Jadarion Price has added 103 carries for 589 yards and 9 scores this season. Malachi Fields leads the team with 596 yards and five touchdowns on 32 receptions. Gordon Faison has added 44 catches for 551 yards and three scores. Make sure you know about how the fans are looking on prediction markets for Notre Dame with the Onyx Odds promo code.

Syracuse vs Notre Dame Prediction

Despite the early-season struggles, Notre Dame has emerged as one of the best teams in the country and will continue to roll this week. Look for the Fighting Irish to dominate this game on both sides of the ball against a mediocre Syracuse team. Take Notre Dame and blowout fashion this week to pick up their ninth victory of the season with a resounding win and cover at home. Final Score Prediction, Notre Dame Fighting Irish win and cover 56-13. Getting the most out of your bets on Syracuse vs Notre Dame can be done by using the Fanatics Sportsbook promo code.

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