TCU vs Houston Picks and Prediction for Saturday November 22 2025

By: Eddie Kline Updated 11/22/2025, 01:22 AM ET

TCU Preview

In Saturday afternoon college football action, the TCU Horned Frogs will travel to TDECU Stadium to face the Houston Cougars. Confident betting starts with the right insights—check out our college football predictions now. The Horned Frogs (6-4) have dropped consecutive games and are averaging 30.7 points per contest. On Saturday, TCU trailed by 17 points at halftime and allowed BYU to possess the ball for more than 36 minutes during a 44-13 road loss.

TCU was losing 24-3 late in the second quarter when Jon Denman ran for a 13-yard touchdown. Eric McAlister caught four balls for a game-high 107 receiving yards. Josh Hoover was picked off twice in a losing effort for the Horned Frogs. Check out all the sportsbook promos to see if you are getting a great deal on your bets on TCU.

Houston Preview

The Houston Cougars have won five of their first seven Big 12 Conference games and still have a chance to reach the conference championship game. The Cougars (8-2) rank fifth in the conference in total defense and are allowing 22.1 points per contest. Last time out, K Ethan Sanchez nailed a short field goal with 2:31 remaining to lift Houston to a 30-27 home victory versus UCF.

Houston got on the scoreboard midway through the second quarter on a 64-yard touchdown pass from Connor Weigman to Amare Thomas. Latreveon McCutchin followed with a 45-yard interception return for a score. Weigman added a game-high 82 rushing yards on 22 attempts for the Cougars. Make sure you know about how the fans are looking on prediction markets for Houston with the Kickr promo code.

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TCU vs Houston Pick

This has been a very evenly matched series over the years and Houston pulled off the upset in 2024 with a 30-19 road victory. The Horned Frogs are coming off a lopsided loss and will respond with a much better effort in this spot. Take TCU to win on the road as a small underdog. Final Score Prediction, TCU Horned Frogs win 30-24. Make sure when you place your bet on TCU vs Houston you are using the BetMGM bonus code.