UCLA vs. Indiana Picks and Prediction for Saturday, October 25, 2025

By: Jake Allman Updated 10/25/2025, 12:00 AM ET

Indiana looks to continue its perfect season when the Hoosiers host the UCLA Bruins at Memorial Stadium in Bloomington on Saturday. The Hoosiers come in 7-0 overall and 4-0 in the Big Ten, while UCLA enters at 3-4 with a 3-1 mark in conference play. Indiana has been dominant all year and holds a 96.4% win probability according to ESPN Analytics. Rivalry week? Bowl season? Stay ahead of the oddsmakers with insider-level college football predictions.

UCLA Preview

UCLA has bounced back after a rough September, stringing together three straight wins, including a 20-17 victory over Maryland and a convincing 38-13 road win at Michigan State. Quarterback Nico Iamaleava has carried the load both through the air and on the ground, throwing for 1,134 yards and nine touchdowns while adding 335 rushing yards and four more scores. Kwazi Gilmer has been his top target with 313 receiving yards and two touchdowns. The Bruins have improved recently on offense, but turnovers and inconsistent red-zone execution remain issues that could be costly against a team such as Indiana. UCLA’s ability to sustain drives and keep Fernando Mendoza off the field will be critical to any upset hopes.

Indiana Preview

Indiana has been one of the most balanced and explosive teams in the country, averaging blowout wins in recent weeks. Quarterback Fernando Mendoza has been superb, completing 71% of his passes for 1,423 yards and 17 touchdowns against just two interceptions. The passing game runs through Elijah Sarratt, who leads the Hoosiers with 533 yards and seven scores, while running back Roman Hemby adds steady balance on the ground with 421 rushing yards. On the other side of the ball, linebacker Isaiah Jones has 4.5 sacks, and Louis Moore anchors the secondary with 38 tackles. Indiana’s dominance has been built on execution, a low turnover rate, and the ability to finish drives effectively, all traits that have fueled its undefeated start.

UCLA vs Indiana Prediction

The betting markets will almost certainly list Indiana as a heavy home favorite, and rightfully so. UCLA’s improvement gives them a chance to cover a large spread, but it’s hard to see the Hoosiers slipping at home with Mendoza in full command. Expect Indiana’s offense to dictate the tempo early, forcing UCLA to chase the game and lean too heavily on Iamaleava’s legs.

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Prediction: Indiana 45, UCLA 17