UConn vs Syracuse Picks and Predictions for Saturday September 6 2025

By: David Anicetti Updated 09/05/2025, 12:10 PM ET

UConn Preview

The UConn Huskies visit JMA Wireless Dome in Syracuse, New York Saturday to play the Syracuse Orange. UConn opened its regular season on Saturday with a 59-13 rout of Central Connecticut. UConn held the Blue Devils to just 257 yards of total offense, while the Huskies' offense generated 681 yards of total offense. UConn had 26 first downs compared to just 13 for Central Connecticut. Keep up to date with all the college football action with our expert college football picks.

UConn quarterback Joe Fagnano has thrown for 260 yards with three touchdowns. The leading rusher for UConn is Cam Edwards with 115 yards and one touchdown, while the leading receiver is Skyler Bell with 135 yards and two touchdown receptions. UConn’s leading tackler is linebacker Tyquan King with eight. UConn’s defense made one sack but did not intercept any passes.

Syracuse Preview

The Syracuse Orange opened the regular season on Saturday with a 45-26 loss to the No. 24-ranked Tennessee Volunteers. Syracuse performed well on offense, gaining 377 yards, but committed two costly turnovers. The Syracuse defense struggled, allowing 495 yards of total offense to Tennessee. One of Syracuse’s two turnovers was a 22-yard fumble return for a touchdown by Tennessee.

Syracuse quarterback Steve Angell has thrown for 274 yards with one touchdown and one interception. Yasin Willis is the leading rusher with 91 yards and three touchdowns, while the leading receiver is Johntay Cook II with 58 yards and one touchdown reception. Defensive lineman David Reese leads all tacklers with seven. Syracuse did not have any sacks or interceptions in the opening game.

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Syracuse vs UConn Pick

The Syracuse offense looked solid in its opening game loss to Tennessee and will face a much less talented and experienced UConn side at home on Saturday. UConn won big in its season opener, but faces a far more talented Syracuse team than Central Connecticut, and the Huskies will find it difficult to move the ball as easily against Syracuse. Final Score Prediction: Syracuse Orange win and cover ATS 34-17.