USC vs Notre Dame Picks and Prediction for Saturday, October 18, 2025

By: Cameron Ross Updated 10/17/2025, 09:12 PM ET

USC vs Notre Dame Information

The USC Trojans return to the road this week with a game inside Notre Dame Stadium at 7:30 PM against the Notre Dame Fighting Irish. USC is the #20-ranked team in the nation with five wins and one loss overall following an 18-point home victory against Michigan last time out. The Notre Dame Fighting Irish are the number 13 team in the nation with four wins and two losses on a 4-winning streak after a 29-point victory against North Carolina State in their last outing. Stating the action with our College Football Picks.

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USC Preview

Offensively, USC has been stout this season, averaging 45.5 points per game overall. Defensively, USC has been strong, holding opponents to 21.3 points per game through six games. Jayden Maiava has led the way for the USC offense this season with 1852 yards and 13 scores on 123 completions. Waymond Jordan leads the team with 576 yards and five scores on 88 carries this season. Makai Lemon is the top receiver on the roster with 682 yards and six touchdowns on 44 receptions.

Notre Dame Preview

The Notre Dame defense has been mediocre this season, allowing 20.8 points per game overall, but has allowed 34 points per game in their two losses. The Notre Dame offense has been the team's biggest strength, averaging exactly 40 points per game through six games played. CJ Carr orchestrates the Notre Dame offense, leading the way with 1622 yards and 13 scores on 105 completions. Jeremiyah Love leads the team out of the backfield with 530 yards and eight scores on 100 carries. Jadarian Price has come up big for Notre Dame this season with 422 yards and seven scores on 63 carries. Jordan Faison leads the team with 376 yards and two scores on 29 grabs.

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USC vs Notre Dame Prediction

This is a long-standing rivalry as each team will look to make a statement this week. After a tough start, Notre Dame has figured things out and comes into this matchup on a 4-game winning streak. Look for Notre Dame to do the work on their home field this week to get the win, but USC has the talent and depth to cover the number as they come into this week ranked inside the top 25. Final Score Prediction, Notre Dame Fighting Irish win, but the USC Trojans cover 28-24.