USC vs Purdue Picks and Predictions for Saturday, September 13, 2025

By: Cameron Ross Published 09/08/2025, 02:03 AM ET

USC vs Purdue Game Information

USC Trojans carry an undefeated record on the road this week with a game in West Lafayette against the Purdue Boilermakers in Ross-Ade Stadium at 3:30 PM. The USC Trojans are undefeated through two games coming into this week, following a blowout 39-point victory over Georgia Southern a week ago. Purdue stays home this week undefeated through two games after a 17-point victory against SIU in their last game. For more College News, see our College Football Picks.

USC Preview

Jayden Maiava leads the USC offense this season with 707 yards and six scores on 31 completions. Husan Longstreet has added 13 completions for 103 yards and one score. Waymond Jordan leads the team with 209 yards and two touchdowns on 21 carries, and King Miller has added seven carries for 135 yards and two touchdowns. Makai Lemon leads all receivers on the team with 11 catches for 248 yards and two touchdowns.

Purdue Preview

Ryan Browne leads the Purdue offense this season with 481 yards and four touchdowns on 32 completions. Devin Mockobee boasts a team-high 185 yards and three touchdowns on 46 carries. Arhmad Branch leads the team with five catches for 132 yards and two scores. Michael Jackson the third has added seven catches for 79 yards and one touchdown.

USC vs Purdue Prediction

Both teams are playing good football coming into this week, as each is undefeated through two games. Expect a back-and-forth affair to happen early on before USC takes control. Look for the Trojans to pull away late to get the win, but Purdue will play well enough at home to cover the big number. Final Score Prediction, USC Trojans win, but the Purdue Boilermakers cover 42-31.

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