Vanderbilt at Virginia Tech Picks and Prediction September 6 2025

By: Dylan Hellebrand Published 09/01/2025, 08:56 PM ET

Vanderbilt vs Virginia Tech Game Info

On Saturday, the Vanderbilt Commodores (1-0) face off against the Virginia Tech Hokies (0-1) at Lane Stadium in Blacksburg, Virginia. The game will air on the ACC Network. Make sure you are ready for all the football action with our college football picks.

Virginia Tech Preview

Virginia Tech comes into this matchup having lost their first game of the season. In their 24-11 defeat against South Carolina, Virginia Tech’s quarterback Kyron Drones completed 15 of his 35 passing attempts, throwing for 221 yards but also tossing two interceptions. On the ground, running back Marcellous Hawkins led the team with 58 rushing yards, while Drones himself contributed an additional 26 rushing yards. Wide receiver Donavon Green emerged as the primary target in the passing game, hauling in 94 receiving yards. Defensively, the Hokies have recently struggled, giving up an average of 24 points over their last five games. As they begin this new season, Virginia Tech is aiming to secure their first victory and set a positive tone for the year. Last season, the Hokies’ offense averaged 28.2 points per game, suggesting they have the potential to rebound if they can reduce turnovers and tighten up on defense. Virginia Tech is favored by 1.5 points with the over/under set at 47.5 total points.

Vanderbilt Preview

Vanderbilt enters this game on a one-game winning streak. In a commanding 45-3 victory over Charleston Southern, Vanderbilt quarterback Diego Pavia delivered an impressive performance, completing 20 of his 25 passing attempts. He racked up 275 yards through the air and connected for three touchdown passes, effectively leading the Commodores’ offense. On the ground, running back Sedrick Alexander contributed 83 rushing yards, while Pavia himself added 44 yards with his legs. Tight end Eli Stowers emerged as a key target in the passing game, hauling in receptions for a total of 86 receiving yards. Defensively, the Commodores have been relatively solid, allowing an average of just 23.6 points per game over their last five games, spanning back to the end of last season. Heading into the second week, Vanderbilt is aiming to maintain their undefeated record. Offensively, the team averaged 25 points per game last season.

Vanderbilt vs Virginia Tech Trends

Vanderbilt was 2-3 on the road last season
The Commodores averaged 24.7 points on the road
Virginia Tech was 4-2 at home last season
The Hokies averaged 28 points at home

Virginia Tech vs Vanderbilt Pick

Virginia Tech is still searching for their first victory of the season and hopes to turn things around as they host Vanderbilt in Blacksburg. Meanwhile, Vanderbilt arrives with an unblemished record and will be aiming to keep their winning streak alive. The Commodores will be looking to put up a strong performance and challenge the Hokies on the road. Final Score Prediction, Virginia Tech Hokies win and cover the spread, 23-20.

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