Virginia vs Duke Picks and Prediction for Saturday November 15 2025

By: Eddie Kline Updated 11/15/2025, 12:12 AM ET

Virginia Preview

Wallace Wade Stadium will play host to a Saturday afternoon college football clash between the Virginia Cavaliers and the Duke Blue Devils. Maximize your wagers by reading our free college football picks before kickoff. The 14th ranked Cavaliers (8-2) are locked in a four-way tie for first place in the ACC Conference standings and are scoring 36.4 points per game. On Saturday, Virginia turned the ball over three times and failed to score a touchdown during a 16-9 home loss versus Wake Forest.

Virginia kicker Will Bettridge nailed field goals of 34, 21, and 40 yards. Senior RB J’Mari Taylor carried 19 times for a game-high 98 yards. Trell Harris added 60 receiving yards on six receptions for the Cavaliers, who outgained the Demon Deacons by a 327-203 margin.

Duke Preview

The Duke Blue Devils have won four of their first five ACC Conference games and still have a shot to reach the championship game. The Blue Devils (5-4) rank third in the conference in total offense and are scoring 35.4 points per contest. On Saturday, Duke committed three costly turnovers during a 37-34 road loss against UConn.

Duke QB Darian Mensah completed 22 of 31 passes for 222 yards and three touchdowns. Nate Sheppard rushed for a game-high 100 yards on 16 attempts and hit pay dirt twice. Jeremiah Halsel added 61 receiving yards and a score for the Blue Devils.

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Virginia vs Duke Pick

Virginia leads the all-time series versus Duke with a 41-34 record and won the most recent meeting by a field goal in 2023. The Blue Devils are unranked and yet they are favored by nearly a touchdown against the 14th ranked Cavaliers. Take Duke to win and cover at home. Final Score Prediction, Duke Blue Devils win 38-21.