Virginia vs Louisville Picks and Prediction for Saturday, October 4, 2025

By: Cameron Ross Updated 10/03/2025, 11:00 PM ET

Virginia vs Louisville Information

The Virginia Cavaliers return to the road this week with the game in Louisville, Kentucky, for a matchup against the Louisville Cardinals at 3:30 PM in L&N Federal Credit Union Stadium. Virginia has been solid this season with four wins and one loss overall, riding a three-game winning streak following an 8-point double overtime home victory against Florida State last week. The Louisville Cardinals returned to their home field this week, perfect on the year through four games, following the seven-point victory on the road a week ago. Get the edge this weekend with our free college football picks backed by data and trends.

Virginia Preview

Offensively, Virginia has been a smoke show this season, averaging 45.6 points per game and 49.25 points per game in their four victories. Defensively, Virginia has been mediocre, allowing 23.2 points per game this season. Chandler Morris leads the Virginia offense this season, with 1239 yards and 10 scores on 111 completions. J’Mari Taylor leads the Cavaliers with 75 carries for 397 yards and seven scores, while Harrison Waylee has added 229 yards and four touchdowns on 30 carries. Trell Harris leads the team with 306 yards and three touchdowns on 7 catches.

Louisville Preview

The Louisville offense has been consistent this year for the Cardinals, averaging 38.25 points per game through four games played. Defensively, Louisville has been stout, holding opponents to an average of 18.75 points per game this season. Miller Moss is the offensive leader this season for Louisville with 690 yards and two touchdowns on 53 completions. Isaac Brown is the top ball carrier with 248 yards and three touchdowns on 19 carries. Keyjuan Brown has come up big for Louisville this season with 22 carries for 110 yards and three touchdowns. Chris Bell leads the team with 107 yards and one touchdown on 13 receptions.

Virginia vs Louisville Prediction

Both teams are playing good football this season, but Louisville will do the work this week. Look for the Cardinals to control this game on both sides of the ball, as Virginia comes into this game riding a ton of momentum. Take the Cardinals to do the job as they get the winning cover at home to remain undefeated against a conference foe. Final Score Prediction, Louisville Cardinals win and cover 37-24

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