Wake Forest vs Duke Picks and Prediction for Saturday, November 29, 2025

By: Jake Allman Published 11/23/2025, 11:29 PM ET

Wake Forest Prediction

Wake Forest heads into Durham at 8-3 with three straight ACC wins and solid momentum. The Demon Deacons have used a timely offense and a steady run game to control recent matchups. A 52-14 blowout of Delaware followed strong wins over North Carolina and Virginia, helping them recover from a disappointing loss to Florida State. Playing at Wallace Wade Stadium in 45-degree conditions, the challenge will be keeping that rhythm against a Duke team with better passing production. Rivalry week? Bowl season? Our college football predictions keep you ahead.

Quarterback Robby Ashford leads Wake Forest with 1,827 passing yards, seven touchdowns, and six interceptions. He has not produced big numbers, but his stability, paired with Demond Claiborne’s 849 rushing yards and 10 touchdowns, keeps the offense on schedule. Chris Barnes leads the team with 523 receiving yards, though Wake Forest spreads the ball around rather than leaning on one playmaker. Nick Andersen’s 89 tackles anchor a group that holds up well late. The last five games show inconsistency, but the timely plays have fueled this late-season push. Make sure you know about how the fans are looking on prediction markets for Wake Forest with the Thrillz promo code.

Duke Prediction

Duke arrives at 6-5 and relies heavily on Darian Mensah, who has thrown for 3,182 yards and 26 touchdowns with only four interceptions. His effectiveness elevates the entire offense. The 32-25 win at North Carolina showed the ability to end drives with points and control tempo. Even in losses, Duke’s passing game remains dangerous and capable of stretching defenses.

Nate Sheppard supports Duke’s attack with 790 rushing yards and seven touchdowns, giving the offense stability early in drives. Cooper Barkate leads the receiving unit with 895 yards and six scores, consistently creating matchup issues downfield. Vincent Anthony Jr. provides needed pressure with 6.5 sacks. Duke has explosive upside, though losses to Virginia and UConn earlier in the month underline inconsistency. Make the most of your bets on Duke by using the sportsbook promos.

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Wake Forest vs Duke Prediction

Duke is favored by 3.5 points with a total of 54.5. The market supports Duke's passing advantage and home field. Wake Forest’s recent form makes them a viable underdog, but Duke’s ability to control game flow through the air gives them the upper hand. Make sure when you place your Wake Forest vs Duke bet you are using the bet365 bonus code.

Prediction: Duke pulls away late with a more reliable offense. Duke 30, Wake Forest 24.