Western Kentucky vs LSU Picks and Predictions for Saturday, November 22, 2025

By: David Anicetti Updated 11/22/2025, 01:31 AM ET

Western Kentucky (8–2) heads to Baton Rouge to take on LSU (6–4) in a non-conference showdown under the lights at Tiger Stadium. The Hilltoppers have bounced back from an October loss to FIU with three straight wins, including a 42–26 victory over Middle Tennessee. LSU snapped a three-game skid with a 23–22 home win over Arkansas and now looks to avoid an upset against a dangerous Group of 5 offense. Looking for today’s college football picks? Don’t miss our expert breakdowns.

Western Kentucky vs LSU Game Information

Kickoff: 7:45 PM ET, November 22
Where: Tiger Stadium, Baton Rouge, LA
TV: SEC Network

Western Kentucky Preview

Western Kentucky brings a strong passing attack, led by quarterback Maverick McIvor. He has 1,863 passing yards with 12 touchdowns and five interceptions, completing over 67% of his throws. Backup Rodney Tisdale has also been sharp with 688 yards and six touchdowns, giving the Hilltoppers plenty of depth at quarterback. Matthew Henry leads the receivers with 568 yards and five scores, while K.D. Hutchinson adds 490 yards and three touchdowns. Marvis Parrish and La’Vell Wright pace the ground game, combining for over 560 rushing yards and seven scores.

On defense, linebacker Jaylen Wester leads Western Kentucky with 58 tackles, and defensive back Jaylen Lewis has two interceptions. The pass rush is spread around, with Dominic Oliver and Harper Holloman both able to get pressure. Betting on sports and on Western Kentucky is easy, but even easier if you use the best sportsbooks.

LSU Preview

LSU is led by quarterback Garrett Nussmeier, who has 1,927 passing yards with 12 touchdowns and five interceptions on 67.4% passing. The Tigers rotate several backs, with Caden Durham (382 yards, two touchdowns) and Harlem Berry (291 yards, two scores), and Ju’Juan Johnson adding 139 rushing yards and two touchdowns. In the passing game, Barion Brown has 405 yards, while Aaron Anderson and Zavion Thomas have combined for over 700 yards and three scores.

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Safety A.J. Haulcy anchors the defense with 65 tackles and two interceptions, and linebacker Harold Perkins Jr. remains the top pass rusher with three sacks and a forced fumble. Make sure you know about how the fans are looking on prediction markets for LSU with the Novig promo code.

Western Kentucky vs LSU Prediction

Western Kentucky’s passing game can move the ball and put some stress on LSU’s secondary, but the Tigers have the more talented roster and the advantage up front on both sides of the ball. Over four quarters, LSU’s run game and defense will wear down the Hilltoppers. Final Score Prediction: LSU Tigers win and cover ATS, 39–14. Make sure when you place your bet on Western Kentucky vs LSU you are using the BetMGM bonus code.