Wofford vs Virginia Tech Picks and Predictions for Saturday, September 20, 2025

By: David Anicetti Published 09/14/2025, 09:05 PM ET

Wofford visits Virginia Tech on Saturday in Blacksburg, with both teams still winless at 0–3. The Terriers come in off a 22–21 loss at Mercer, while the Hokies were beaten 45–26 at home by Old Dominion. The opening kickoff is scheduled for 12:00 PM ET and can be seen on ESPN+. Follow all the college football action with our expert college football picks

Wofford Preview

The Terriers have dropped three close games by a combined six points. Quarterback Ethan Drumm has completed 18 passes for 279 yards with three touchdowns. The ground attack has been steadier, led by Ihson Jackson-Anderson, who averages nearly 7.0 yards (154 yards) per carry. Isaiah Scott has caught five passes for 119 yards and one touchdown. Pass protection remains a problem, as Wofford has already given up five sacks.

Defensively, Jalen Rambert has tallied 24 tackles, while Brandon Maina provides pressure up front with two sacks. The secondary has produced three interceptions, including a 72-yard return by CJ Coombes. This group has kept games close against FCS opponents, but facing Virginia Tech’s bigger and faster lineup is a different challenge.

Virginia Tech Preview

The Hokies’ offense has mixed bright moments with mistakes. Kyron Drones has thrown for 621 yards with four touchdowns and three interceptions. His best connection is with Donavon Greene, who has 193 yards on nine catches. Drones leads the rushing game with 127 yards and two touchdowns.

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Virginia Tech’s defense holds the biggest edge in this matchup. The front has generated four sacks spread across several linemen. Linebacker Caleb Woodson leads the team with 24 tackles, while Quentin Reddish has the Hokies’ only interception. Special teams are also reliable, with John Love perfect on five field goals, including a 56-yarder.

Wofford vs Virginia Tech Prediction

Virginia Tech’s defensive front should control the line and limit Wofford’s run game. With a stable kicker turning drives into points, the Hokies are in position to pull away after halftime. Virginia Tech wins by multiple scores. Fine Score Prediction: Virginia Tech Hokies win and cover ATS 37-3.