Arizona Cardinals vs New Orleans Saints Picks and Predictions for Sunday September 7

By: Cameron Ross Updated 09/08/2025, 09:03 AM ET

Arizona Cardinals Preview

The Arizona Cardinals begin the new season in week one with the game down South in New Orleans against the New Orleans Saints. Arizona was up and down a year ago, finishing the season with eight wins and 9 losses, following a 23-point home victory against the San Francisco 49ers in the final game of the season. Defensively, Arizona had its issues all year, allowing 22.2 points per game overall. Offensively, the Cardinals were mediocre overall, scoring 23.5 points per game, including 47 in the final game of the year. Stay up to date with our NFL Picks.

Kyler Murray will again be the Arizona starting quarterback after throwing for 3,851 yards and 21 touchdowns on 372 completions, along with 572 yards and five scores on 78 carries, a year ago. James Conner will be the Arizona lead back again this season after 1094 yards and eight scores on 236 carries across 16 games. Marvin Harrison Jr. returns this season after 885 yards and eight scores on 62 catches a year ago.

New Orleans Saints Preview

The New Orleans Saints enter this season aiming to improve on a disappointing campaign a year ago. New Orleans finished last season with just five wins and 12 losses overall after winning the first two games of the year. The New Orleans offense was below average, scoring just 19.2 points per game the previous year. Defensively, New Orleans had their issues, allowing 23.4 points per game last season.

Spencer Rattler will step into a starting role this season for New Orleans after quarterback Derek Carr retired in the offseason. Rattler has thrown for 1317 yards and four scores on 138 completions during his career. Alvin Kamara will be a big piece to the New Orleans offense early after 950 yards and six scores on 228 carries a year ago.

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Saints vs Cardinals Pick

The Arizona Cardinals will have the edge this week as New Orleans will send out a young quarterback. Look for Arizona to do the work on both sides of the ball to overwhelm New Orleans from start to finish in week 1. Take the Cardinals to do enough to get the win and cover on the road. Final Score Prediction, Arizona Cardinals win and cover 34-14.