Buffalo Bills at Carolina Panthers Picks and Predictions for Sunday, October 26, 2025

By: David Anicetti Published 10/26/2025, 12:00 AM ET

The Buffalo Bills visit the Carolina Panthers at Bank of America Stadium on Sunday, with the opening kickoff at 1:00 PM ET on FOX. Buffalo is 4–2 in the AFC East and comes off a bye. Carolina is 4–3 in the NFC South and 3–0 at home in Charlotte. Carolina beat the New York Jets 13-6 on Sunday. Throw a touchdown pass and win with our free NFL Picks.

Game Information for Bills vs Panthers

Day/Date: Sunday, October 26

Time: 1:00 PM ET

Where: Bank of America Stadium, Charlotte, NC

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

TV: FOX

Buffalo Bills Preview

Josh Allen is 122-of-178 for 1,397 yards, 11 touchdowns, and four interceptions. James Cook has 537 rushing yards on 107 carries with five scores. Khalil Shakir adds 25 catches for 268 yards and two touchdowns. Keon Coleman has 24 receptions for 237 yards and two touchdowns. The Bills offense has been its strength thus far this season. Limiting penalties and finishing red-zone trips will make Buffalo tough to beat.

Buffalo dropped two straight before the bye and needs to convert more third-down plays. The defense can set the tone with pressure and tighter coverage. Terrel Bernard leads with 30 tackles and one interception. Injuries: Joshua Palmer (Q), DaQuan Jones (Q), Terrel Bernard (Q), Matt Milano (Q), Curtis Samuel (Q).

Carolina Panthers Preview

Bryce Young is questionable with an ankle injury. The Panthers’ QB is 138-of-224 for 1,288 yards, 11 touchdowns, and five interceptions. Rico Dowdle has 551 rushing yards and two touchdowns to lead the Panthers. Tetairoa McMillan leads with 30 receptions for 413 yards and two touchdowns. Sustained drives and not committing turnovers are the priorities.

Carolina has won three of four and has performed well at home. Linebacker Christian Rozeboom leads with 50 tackles. Derrick Brown has three sacks and anchors the interior. Jaycee Horn has three interceptions and can change a drive with one play. Injuries: Bryce Young (Q), Damien Lewis (Inactive), Hunter Renfrow (Inactive), James Mitchell (Inactive), Cam Jackson (Inactive).

Buffalo Bills vs. Carolina Panthers Prediction

Buffalo brings the stronger passing game and a better defensive front seven. Allen’s arm plus Cook’s legs will create steady gains against the Carolina defense. If Bryce Young plays, he is unlikely to be at full strength on a tender ankle, which gives even more advantage to Buffalo. Final Score Prediction: Buffalo Bills win and cover ATS 27–17.