Carolina Panthers vs Buffalo Bills Picks and Prediction for Saturday August 15 2026
Panthers Preview
In Saturday afternoon NFL preseason action, the Carolina Panthers will travel to Highmark Stadium to take on the Buffalo Bills. Get ready for all the football action with our NFL Picks. The Panthers (8-9) have endured eight consecutive losing seasons and somehow managed to win the NFC South Division despite having a minus 69 point differential. Former number one overall draft pick Bryce Young is coming off his best season as a pro, throwing for 3,011 yards and 23 touchdowns. Carolina should be improved on defense with the addition of LB Jaelen Phillips, who has registered 28 sacks in 63 career NFL games.
On Thursday, rookie QB Haynes King scored a five-yard rushing touchdown as time expired to lift Carolina to a 33-30 victory versus Arizona in the Hall of Fame Game. King also completed 21 of 34 passes for 180 yards and two scores.
Bills Preview
The Buffalo Bills have won at least ten games in seven consecutive seasons and are in search of their first Super Bowl title in franchise history. The Bills (12-5) finished fourth in the NFL in total offense and averaged 28.3 points per game. With QB Josh Allen (25 pass TDs) driving the bus and newly acquired WR D.J. Moore in the fold, Buffalo should remain a top-five offensive attack. RB James Cook III rushed for a career-best 1,621 yards and found the end zone 14 times in 2025.
Buffalo ranked seventh in the league in total defense and held their opponents to 21.5 points per contest. The Bills made a major move in the offseason to improve their pass rush by signing OLB Bradley Chubb to a three-year deal. Chubb has recorded at least eight sacks in each of the previous three seasons.
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Panthers vs Bills Pick
Carolina head coach Dave Canales is 2-5 SU and 1-6 ATS in his first three preseasons, while new Buffalo head coach Joe Brady will look to get off to a solid start. The Bills will play their starters in this game, but it is not clear how many series they will remain on the field. Take Buffalo to win and cover at home. Final Score Prediction, Buffalo Bills win 20-13.
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