Chicago Bears at San Francisco 49ers, Picks and Prediction for Sunday, December 28, 2025
The Chicago Bears travel west to face the San Francisco 49ers on Sunday, December 28, 2025, at Levi’s Stadium. Get in on the action with our free NFL picks.
Chicago Bears Analysis
The Bears continue to build around a young core, focusing on defensive improvement and offensive consistency.
Team Overview and Metrics
Chicago averages around 23 points per game, with offensive production tied closely to quarterback efficiency and rushing success. Defensively, the Bears allow around 24 points per game, showing progress in pass defense but still struggling against elite offensive lines.
Strengths
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Defensive front: Chicago’s pass rush has improved, creating pressure without excessive blitzing.
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Quarterback mobility: Caleb Williams (26 total TD's) adds value with off-schedule plays and designed runs.
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Run game: When effective, Chicago can shorten games and limit opponent possessions.
Weaknesses
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Offensive consistency: Sustaining long drives remains a challenge.
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Explosive plays allowed: Big gains have hurt the Bears in road matchups.
San Francisco 49ers Analysis
San Francisco remains one of the NFL’s most complete teams, built around physical defense, offensive balance, and elite skill talent. The 49ers are especially strong at home, where they dictate pace and wear down opponents.
Team Overview and Metrics
The 49ers are coming off a 48-27 dismantling of Indianapolis on the road.
Strengths
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Offensive balance: San Francisco can win through the run or pass without forcing either.
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Skill position depth: Playmakers Christian McCaffrey (1,039 yards) and George Kittle (599 yards) create yards after the catch and explosive scoring chances.
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Defensive dominance: Pressure up front and speed at linebacker limit opponent efficiency.
Weaknesses
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Occasional slow starts: Early drives can lack rhythm before adjustments settle in.
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Injury management: Ricky Pearsall and George Kittle are questionable for this game
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Penalty discipline: Aggressive play sometimes extends opposing drives.
Key Players and Matchups
Chicago
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Caleb Williams: Must avoid turnovers and capitalize on red-zone chances.
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Defensive Line: Generating pressure without blitzing is critical.
San Francisco
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Brock Purdy: 17 touchdowns and 8 interceptions on the year
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Skill players: Versatility and yards after catch stress defensive assignments.
Bears vs 49ers Prediction Reasoning
Chicago may be a popular play with their recent big wins, and having captured the division lead. However, the 49ers looked better than ever in their last game, and are playing at home. If Kittle plays, the edge shifts to San Francisco, and even moreso if Pearsall suits up. We like the 49ers at home. Check out all the sportsbook promos to see if you are getting a great deal on your bets on the Bears. Make sure you know about how the fans are looking on prediction markets for the 49ers with the Kickr promo code. Make sure when you place your bet on Bears vs 49ers you are using the BetMGM bonus code.
Final Score Projection: 49ers 27, Bears 20
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Best Picks
- 49ers moneyline
- Under 52.5 total points
