Cleveland Browns vs Detroit Lions Picks and Predictions for Sunday, September 28, 2025

By: David Anicetti Updated 09/26/2025, 12:58 PM ET

The Cleveland Browns visit the Detroit Lions on Sunday at Ford Field, with the kickoff scheduled for 1:00 PM ET on FOX. Cleveland enters at 1–2, sitting 3rd in the AFC North, while Detroit is 2–1 and holds 2nd place in the NFC North. Tap into the psychology of success this NFL season with expert strategies that lead to winning free NFL picks.

Cleveland Browns Preview

The Browns got their first win of the season in Week 3, edging Green Bay 13–10 at home. The defense carried the team, holding the Packers under 200 total yards while Myles Garrett recorded his fourth sack of the year. Offensively, Cleveland still has major questions. Joe Flacco has thrown for 631 yards but has just two touchdowns against four interceptions with a 65.9 passer rating. Rookie running back Quinshon Judkins has been the lone bright spot, averaging 5.5 yards per carry through two games.

Cleveland’s biggest issue has been finishing drives. The Browns have managed only five touchdowns in three games and rank near the bottom of the league in red zone efficiency. Harold Fannin Jr. leads the team in receiving with 136 yards, while Jerry Jeudy and Cedric Tillman have yet to make an impact for the receiving corps. Injuries along the offensive line remain a concern, with both starting tackles banged up heading into this matchup.

Detroit Lions Preview

The Lions bounced back in Week 3 with a 38–30 road win at Baltimore, showing off their offensive firepower. Jared Goff has been sharp to start the season, completing nearly 78% of his passes for 761 yards with seven touchdowns and only one interception. Amon-Ra St. Brown has 20 receptions for 237 yards and four touchdowns, while Jameson Williams adds a deep threat for the Lions with 174 yards on just eight catches.

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On the ground, Detroit’s David Montgomery has 233 yards and three touchdowns, and Jahmyr Gibbs has 180 rushing yards and 18 receptions. Defensively, Jack Campbell and Brian Branch lead an aggressive front seven that has already totaled 11 sacks. Playing at home in front of a raucous crowd cheering them on, the Lions will look to take advantage of a struggling Cleveland offense.

Cleveland Browns vs Detroit Lions Prediction

The Browns’ defense can keep them competitive, but Cleveland’s lack of offensive production is a huge issue. Detroit’s balance on offense, with Goff’s passing and Montgomery/Gibbs rushing abilities, will prove too much for even a strong Cleveland defense to stop. Final Score Prediction: Detroit Lions win and cover ATS 27-13.