Houston Texans vs. Jacksonville Jaguars Picks and Prediction for Sunday September 21, 2025

By: Dylan Hellebrand Updated 09/19/2025, 03:15 PM ET

On Sunday, the Houston Texans (0-2) face off against the Jacksonville Jaguars (1-1) at EverBank Stadium in Jacksonville, Florida. The game will be aired on CBS. Stay ahead of the game by using our free NFL picks that harness emotional insights to drive results.

Game Information For Texans vs Jaguars

September 21, 2025, 1:00pm EST, Bank of America Stadium,
TV: FOX
86° sunny/cloudy at start time

Jacksonville Jaguars Form & Recent Results

Jacksonville enters this game looking to bounce back after a narrow defeat and an even 1-1 start to their season. Last weekend, the Jaguars fell to Cincinnati in a close 31-27 contest. Quarterback Trevor Lawrence completed 24 of his 42 pass attempts, racking up three touchdown passes but also throwing two interceptions. Over the first two games of the year, Lawrence has accumulated 449 passing yards. On the ground, running back Travis Etienne Jr. has led the attack with 214 rushing yards. In the receiving corps, Dyami Brown stands out with 109 yards, while both tight end Brenton Strange and wide receiver Parker Washington have contributed 76 receiving yards apiece. Through their first two outings, the Jaguars’ offense is averaging 26.5 points per game, marking a noticeable improvement from last season when they averaged just 18.8 points per game. Jacksonville will be aiming to regroup for a stronger performance after their disappointing game against the Bengals.

Houston Texans Form & Recent Results

The Texans come into this matchup having dropped their first two games of the season. In their 20-19 nail-biting loss to Tampa Bay on Monday night, quarterback C.J. Stroud went 13-for-24 with a touchdown for the Texans. This season, Stroud has thrown for 395 passing yards early on. On the ground, running back Nick Chubb led the team with 103 rushing yards. Among receivers, Jayden Higgins was the top target, hauling in passes for 60 yards, while fellow wideout Xavier Hutchinson contributed 59 yards through the air. Houston now prepares to face a motivated Jacksonville Jaguars squad, who are looking to bounce back following a narrow defeat in their previous game. The Texans will hope to put their first win on the board by holding off the Jaguars’ offense and improving their own efficiency. Looking at last season, Houston averaged 22 points per game, and they’ll aim to rediscover that scoring touch.

Key Players For Texans and Jaguars

Jaguars QB Trevor Lawrence: 43-for-73, 4 TD, 3 INT
Texans QB C.J. Stroud: 32-for-51, 1 TD, 1 INT

Betting Odds & Market Overview:

JAX -1.5; O/U 44.5

Jaguars vs Texans Picks and Prediction

The Jaguars suffered a disappointing defeat last weekend in Cincinnati, where they gave up a last-minute touchdown that sealed the game for the Bengals. Now, Jacksonville returns home, eager to get back on track as they prepare to face division rivals, the Houston Texans. The Texans, meanwhile, will be focused on getting their first win and trying to slow down the Jaguars’ potent offense, which has been firing on all cylinders lately. Final Score Prediction, Jacksonville Jaguars win but fail to cover the spread, 24-23.

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