Indianapolis Colts vs. Los Angeles Rams Picks and Prediction for Sunday, September 28, 2025
Colts vs Rams Preview
The Colts head to Los Angeles on Sunday afternoon looking to extend their unbeaten start, while the Rams aim to bounce back from a road loss to Philadelphia. Indianapolis has opened the season 3-0 after a commanding 41-20 win over Tennessee last week. The Rams sit at 2-1, dropping the most recent contest 33-26 to the Eagles. Kickoff is set for 4:05 PM ET at SoFi Stadium on FOX, with Los Angeles favored by 3.5 points and the total listed at 48.5. Stay ahead of the game by using our free NFL picks that harness emotional insights to drive results.
Colts Preview
Indianapolis has looked sharp across its first three games, led by quarterback Daniel Jones, who has passed for 816 yards while completing over 70% of his throws. He has accounted for three touchdowns and has been in sync with Michael Pittman Jr., who has 193 yards and two scores on 16 receptions. Jonathan Taylor continues to be the engine of the offense, piling up 338 rushing yards on 60 carries with three touchdowns, giving the Colts balance that keeps opposing defenses honest. The offensive line has provided stability in both phases, allowing Jones to manage games effectively while Taylor establishes the ground attack.
Rams Preview
Los Angeles comes into this matchup with plenty of offensive firepower of its own. Matthew Stafford has thrown for 739 yards and five touchdowns, spreading the ball effectively to Puka Nacua, who already has 333 receiving yards on 29 catches. Kyren Williams has added 226 rushing yards with one score, giving the Rams a reliable presence in the backfield. Byron Young has emerged as a tough force on defense with four sacks, while Kam Curl leads the defense with 26 tackles, showing the unit’s ability to make plays despite some inconsistencies against the pass. The Rams have proven they can score quickly, but they also must tighten up against a Colts offense that has been effective early in games.
Colts vs Rams Pick
The spread suggests a close contest, and it likely will be. Indianapolis has demonstrated balance between the run and pass, while Los Angeles leans on Stafford’s arm to stretch defenses. Both teams have playmakers at skill positions, but the Colts’ combination of Taylor’s rushing and Jones’ passing could be enough to control tempo. If the Rams’ pass rush cannot get to Jones, Indianapolis has the edge in sustaining drives.
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Prediction: Colts 27, Rams 24
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Best Bets:
- Colts +3.5
- Over 48.5
- Michael Pittman Jr. anytime touchdown.
