Jacksonville Jaguars vs Arizona Cardinals Picks and Predictions for Sunday, November 23, 2025

By: Cameron Ross Published 11/22/2025, 10:34 PM ET

Jacksonville Jaguars vs Arizona Cardinals Game Information

The Jacksonville Jaguars will be on the road Sunday with the game in State Farm Stadium against the Arizona Cardinals at 4:05 PM. Jacksonville has six wins and four losses this season, but has dropped three of the last five overall despite a 29-point home victory against Los Angeles a week ago. The Arizona Cardinals stay home this week with only three wins through 10 games played, having dropped four of the last five, including two in a row, after a 19-point home loss to the San Francisco 49ers last week. Stay in the loop with our NFL Picks.

Jacksonville Jaguars Preview

Trevor Lawrence leads Jacksonville this season with 2151 yards and 11 scores on 202 completions. Travis Etienne Jr. leads the way out of the Jacksonville backfield with 729 yards and four touchdowns on 154 carries. Brian Thomas Jr. is the top receiver on the roster with 420 yards and one touchdown on 30 receptions this season. Make sure you know about how the fans are looking on prediction markets for the Jaguars with the Thrillz promo code.

Arizona Cardinals Preview

Jacoby Brissett leads the Arizona offense this season with 1570 yards and 10 touchdowns on 142 completions. Kyler Murray has amassed 962 yards and 6 scores on 110 completions this season. Emari Demercado leads the team with 241 yards on 31 carries this season. Bam Knight has added 181 yards and three scores on 53 carries. Trey McBride leads the team with 718 yards and seven touchdowns on 71 receptions. Make the most of your bets on the Cardinals by using the sportsbook promos.

Jacksonville Jaguars vs. Arizona Cardinals Prediction

Both teams have had their struggles over the last few weeks, but Jacksonville is the better team in the better spot in this game. Look for the Jaguars to dominate this game on both sides of the ball against one of the worst teams in the NFL. Take the Jaguars on Sunday to do the job with a win and cover on the road in Arizona. Final Score Prediction, Jacksonville Jaguars win and cover 35-17. Make sure when you place your Jaguars vs Cardinals bet you are using the bet365 bonus code.

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