Jacksonville Jaguars vs Carolina Panthers Picks and Prediction for Sunday September, 7 2025

By: Thomas Pemberton Updated 09/08/2025, 09:04 AM ET

Jaguars Preview

The Jacksonville Jaguars open up their 2025 season at home with the Carolina Panthers in town. The Jaguars have brought in a new head coach as Liam Coen hopes to turn things around. Jacksonville went just 4-13 last season. The Jaguars started last season off by losing their first four games. Stay up to date with our expert's NFL Picks.

QB Trevor Lawrence started just 10 games last season. Lawrence threw 11 touchdowns with 7 interceptions and was sacked 18 times. Lawrence hopes to start an early season connection with rookie WR Travis Hunter. Jacksonville have also added WR Dyami Brown from Washington.

Panthers Preview

The Carolina Panthers have only won eight games combined over the last two seasons. The Panthers started their last season off with a 1-7 record. Carolina ranked last, last season in the points against per game category. The Panthers do welcome back Dave Canales for his 2nd season as the head coach.

The Carolina Panthers will put their trust in QB Bryce Young at the helm. Young played in 14 games last season. Young threw 15 touchdowns with 9 interceptions and was sacked 29 times. The Panthers averaged just 20 points scored per game last season.

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Jaguars vs Panthers Pick

Both Jacksonville and Carolina are both hoping for better seasons than a year ago. The last time the Jaguars faced the Panthers was back in 2023 when they won 26-0. Carolina shows value in this game as a +3.5 underdog. Watch for a tight game throughout with some early season mistakes happening. Final Score Prediction, Jacksonville Jaguars win 23-21 but the Carolina Panthers cover ATS.