Kansas City Chiefs vs Jacksonville Jaguars Picks and Prediction for Monday October 6 2025

By: Eddie Kline Updated 10/06/2025, 10:30 AM ET

Chiefs Preview

EverBank Stadium will play host to a Monday night NFL clash between the Kansas City Chiefs and the Jacksonville Jaguars. Tap into the psychology of success this NFL season with expert strategies that lead to winning free NFL picks. The Chiefs (2-2) have appeared in an unprecedented five of the previous six Super Bowls and are allowing 19 points per game. On Sunday, Kansas City converted all four fourth down attempts and possessed the ball for 35 plus minutes during a 37-20 home victory versus Baltimore.

Two-time MVP Patrick Mahomes connected with JuJu Smith-Schuster and Isiah Pacheco for touchdown passes late in the first half to give Kansas City a 20-7 advantage. Xavier Worthy contributed 83 receiving yards on five receptions for the Chiefs.

Jaguars Preview

The Jacksonville Jaguars selected Heisman Trophy winner Travis Hunter with the number two overall draft pick and are tied with Indianapolis atop the AFC South Division standings. The Jaguars (3-1) rank in the top ten in total offense (348.5 ypg) and are scoring 24 points per contest for rookie head coach Liam Coen. Last week, Jacksonville built an 11-point halftime lead and forced four turnovers during a 26-21 road victory against San Francisco.

Jacksonville RB Travis Etienne Jr. continued his strong start to the season with 124 rushing yards and a score. Trevor Lawrence found Hunter Long on a four-yard touchdown pass and Parker Washington sealed the win with an 87-yard punt return for a score.

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Chiefs vs Jaguars Pick

Jacksonville DE Travon Walker suffered a wrist injury during Sunday’s victory and will see a specialist to determine his status. The Jaguars lead the NFL with a plus nine turnover margin and the Chiefs are struggling to move the ball on the ground. Take Jacksonville to pull off the upset at home.