Los Angeles Chargers vs New York Giants Picks and Prediction for Sunday September 28 2025

By: Thomas Pemberton Updated 09/26/2025, 01:07 PM ET

The New York Giants will host their second straight home game in Week 4 when they host the Lost Angeles Chargers. The Giants are still seeking their first win of the season. While the LA Chargers are hoping to remain undefeated. The Chargers are a -6.5 road favorite and the over/under is set at 44 points. Don’t miss your chance to elevate your NFL experience with free NFL picks that ignite your desire to win.

New York Giants Preview

The New York Giants limp into Week 4 with a 0-3 record. The Giants are 0-1 at MetLife Stadium. New York lost to the Chiefs in their home opener last week 22-9. The Giants were shutout in two quarters in that game and allowed points in all four quarters. QB Russell Wilson threw for 160 yards in the loss with no touchdowns and 2 interceptions. Wilson has 3 passing touchdowns on the season with 3 interceptions. WR Malik Nabers has been Wilson's top target. Nabers has 16 catches on the season and 2 touchdowns.

Los Angeles Chargers Preview

The Los Angeles Chargers are feeling good as they roll into Week 4 of action. The Chargers are 3-0 on the season with a 1-0 road record. The Chargers have scored at least 20 points in all three games this season. Los Angeles beat Denver at home last week 23-20. QB Justin Herbert threw for 300 yards in the win with a touchdown and an interception. Herbert has 6 passing touchdowns on the season with 1 interception. Veteran receiver Keenan Allen leads the Chargers with 19 catches on the season. Allen has 194 receiving yards and 3 touchdowns.

Chargers vs Giants Free Picks & Predictions

The New York Giants are a tough team to get behind this season as they look just awful. The Giants are 1-2 against the spread. While the Chargers are 2-0-1 against the spread. The Chargers beat the Giants 37-21 in their last meeting back in 2021. Lay the points with the better team as the Chargers offense will be too much for the Giants to keep pace with.

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