Los Angeles Rams vs Arizona Cardinals Picks and Prediction for Sunday, December 7, 2025

By: Jake Allman Published 12/03/2025, 01:20 AM ET

The Los Angeles Rams look to bounce back from a loss at Carolina as they head to Arizona for a divisional matchup. At 9-3, the Rams stay in control of their playoff positioning, and the offense continues to move the ball behind Matthew Stafford’s 3,073 passing yards and 32 touchdowns. Arizona sits at 3-9 and has dropped four straight. Jacoby Brissett has been steady, but the injuries continue to pile up and the defense has struggled to slow opponents over the past month. This matchup features two teams on opposite paths. From underdogs to point spreads, we’ve got the sharpest NFL picks.

Kickoff is set for 4:25 PM ET at State Farm Stadium on FOX. The Rams are 4-2 on the road, while the Cardinals are only 1-5 at home. Arizona again plays without Kyler Murray, who remains on IR with a foot injury. The dome takes weather out of the equation.

Rams Preview

Los Angeles enters with strong form after winning four of the last five, including dominant performances against Tampa Bay, Seattle, and New Orleans. Matthew Stafford has been sharp with only four interceptions in 401 attempts. Puka Nacua leads the receiving corps with 1,019 yards on 86 catches, and Kyren Williams gives the backfield enough balance with 868 rushing yards and seven touchdowns. The mistakes on defense last week were more about late-game breakdowns than anything systemic. Byron Young continues to produce with 10 sacks, and the pass rush sets the tone. Injuries exist, but none shift the overall matchup in a significant way.

Cardinals Preview

Arizona continues to battle through a rough season. The Cardinals have dropped four straight, and three of those losses came by double digits. Jacoby Brissett has thrown for 2,188 yards with only four interceptions, which keeps them competitive, but the offense lacks explosive plays. Bam Knight leads the run game with 255 yards and four touchdowns, and Trey McBride has been a bright spot with 879 yards and eight scores. The issue has been holding up over four quarters. Josh Sweat leads the defense with 11 sacks, but coverage breakdowns and missed assignments have been costly. With several defensive starters either questionable or inactive, that remains a concern.

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Cardinals vs Rams Pick

The Rams hold advantages at quarterback, offensive weapons, and overall defensive consistency. Los Angeles 30, Arizona 20. Betting on sports and on the Cardinals is easy, but even easier if you use the best sportsbooks. Make sure you know about how the fans are looking on prediction markets for the Rams with the social sportsbooks. Getting the most out of your bets on Cardinals vs Rams can be done by using the Fanatics Sportsbook promo code.