Los Angeles Rams vs Philadelphia Eagles Picks and Predictions for Sunday, September 21, 2025

By: David Anicetti Updated 09/19/2025, 03:12 PM ET

The Los Angeles Rams visit the Philadelphia Eagles at Lincoln Financial Field on Sunday at 1:00 PM ET on FOX. The Rams are 2–0 (1–0 away) after beating Tennessee 33–19, while the Eagles are also 2–0 (1–0 home) following a 20–17 win at Kansas City. The current odds are Eagles -3.5, total 45.5, Rams +165 on the moneyline, and the Eagles -195. Stay ahead of the game by using our free NFL picks that harness emotional insights to drive results.

Los Angeles Rams Preview

Matthew Stafford has started strong with 543 yards, three touchdowns, and just one interception while completing 71% of his passes. Puka Nacua has been the top target with 18 receptions for 221 yards, while Davante Adams has added 157 yards and a score. Kyren Williams gives balance to the offense with 132 rushing yards and a touchdown. The offensive line has had some injury issues, but Stafford has been sacked only four times in two games. On defense, Byron Young has three sacks, and the Rams have held opponents to under 20 points in both wins.

The Rams’ game plan is built on spreading the field and using Nacua and Adams to stretch defenses. If Williams can provide steady gains on the ground and Stafford protects the football, Los Angeles has the talent to keep this game close.

Philadelphia Eagles Preview

The Eagles are also unbeaten, relying on a powerful running attack. Jalen Hurts has been effective, completing 76% of his passes for 253 yards, though he has not thrown for a touchdown yet. He has done plenty with his legs, scoring three rushing touchdowns. Saquon Barkley leads the backfield with 148 yards and two touchdowns, giving Philadelphia a dependable ground game. The offensive line continues to control the trenches, helping the Eagles average 140 rushing yards per game.

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Defensively, Philadelphia has performed well. Zack Baun leads the unit with 15 tackles, while Andrew Mukuba has an interception. The pass rush has been strong across the front seven, and the secondary has kept big plays to a minimum. At home, the Eagles will look to run the ball, control the clock, and pressure Stafford into mistakes.

Rams vs Eagles Prediction

This matchup features two unbeaten teams with very different strengths. The Rams have been sharp through the air behind Stafford, while the Eagles rely on their rushing attack and physical defense. In a tight contest, the home-field edge and stronger running game give Philadelphia the slight advantage, but LA will play well enough to cover. Final Score Prediction: Philadelphia Eagles win but fall short ATS 23-21.