Miami Dolphins vs Buffalo Bills Picks and Prediction for Thursday September 18 2025

By: Eddie Kline Published 09/15/2025, 10:22 PM ET

Dolphins Preview

The week three NFL schedule will kick off on Thursday night with a matchup between the Miami Dolphins and the Buffalo Bills from Highmark Stadium. Get ready for all the football action with our NFL Picks. The Dolphins (0-2) rank near the bottom of the league in total defense and are surrendering 33 points per contest. On Sunday, Miami committed ten penalties and allowed five sacks during a 33-27 home loss versus New England.

Miami took a 27-23 lead midway through the fourth quarter on Malik Washington’s 74-yard punt return touchdown, but gave up a New England touchdown on the ensuing kickoff. Tua Tagovailoa completed 26 of 32 passes for 315 yards and two scores. Disgruntled WR Tyreek Hill added a game-high 109 receiving yards for the Dolphins.

Bills Preview

The Buffalo Bills made it to the AFC Conference Championship Game last season and are currently the betting favorite to win their first Super Bowl in franchise history. The Bills (2-0) rank first in the league in total offense and are scoring 35.5 points per game. Last week, Buffalo built a 17-point halftime advantage and limited New York to 154 yards during a 30-10 road triumph.

RB James Cook (132 rush yds) started the scoring for Buffalo with a one-yard score and added an impressive 44-yard touchdown in the second quarter. Matt Prater nailed three field goals for the Bills, who possessed the ball for more than 38 minutes.

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Dolphins vs Bills Pick

Buffalo DT Ed Oliver missed Sunday’s victory with an ankle injury and is listed as questionable for this game. Through two games, Miami has been a major disappointment and they have the worst offensive line in football. Take the Bills to win and cover in a rout. Final Score Prediction, Buffalo Bills win 35-14.