Pittsburgh Steelers vs New England Patriots Picks and Predictions for Sunday, September 21, 2025

By: David Anicetti Updated 09/19/2025, 03:13 PM ET

The Pittsburgh Steelers (1–1) visit the New England Patriots (1–1) at Gillette Stadium in Foxborough on Sunday at 1:00 PM ET on CBS. Pittsburgh opened the season with a road win over the Jets before falling to Seattle, while New England dropped its home opener to Las Vegas but bounced back with a win over Miami. The current odds are Steelers -1.5, total 44.5, with moneylines PIT -115 and NE -105. Don’t miss your chance to elevate your NFL experience with free NFL picks that ignite your desire to win.

Pittsburgh Steelers Preview

QB Aaron Rodgers has started strong with 447 passing yards, five touchdowns, and two interceptions. He has spread the ball effectively, with DK Metcalf and Calvin Austin combining for nearly 200 yards and three touchdowns. Running back Jaylen Warren has been the most versatile weapon, with 85 rushing yards, 108 receiving yards, and a touchdown. The ground game as a whole is averaging just 3.2 yards per carry, so the Steelers have leaned heavily on Rodgers’ arm.

Defensively, Pittsburgh has shown promise but needs to tighten up. Safety Chuck Clark leads with 16 tackles, while linebacker Patrick Queen has been active in the middle. T.J. Watt and Alex Highsmith provide the pass rush, though Highsmith is questionable with an ankle injury. The secondary, anchored by Jalen Ramsey, has already intercepted one pass and will be tested by New England’s deep receiving corps.

New England Patriots Preview

Quarterback Drake Maye has been sharp early, completing 71% of his passes for 517 yards with three touchdowns and just one interception. Maye’s favorite target has been Kayshon Boutte, as Boutte leads the team with 119 yards and a touchdown. Veteran Stefon Diggs and tight end Hunter Henry provide additional options, while Rhamondre Stevenson is leading the ground game with 69 yards, though rushing production has been limited.

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The Patriots’ defense has relied on pressure from Harold Landry, who already has 3.5 sacks. Christian Elliss has 16 tackles, while safety Jaylinn Hawkins has an interception. The kicking game has been inconsistent with two missed extra points, but Andy Borregales is 4-for-5 on field goals with a long of 53 yards. If the defense can pressure Rodgers consistently, New England can keep the game close.

Steelers vs Patriots Prediction

This matchup looks even, with both teams at 1–1 and playing inconsistently overall. Pittsburgh brings the experience of Rodgers and a pass rush capable of disrupting Maye, while the Patriots have shown strength with their quarterback and strong pass rush on the edge. In a close contest, Rodgers’ ability to finish in the red zone gives Pittsburgh a small edge. Final Score Prediction: Pittsburgh Steelers win and cover ATS 28-23.