Same Game Parlay for 49ers vs Rams – Thursday Night Football Best Bets

By: Devin Erickson-Sheehy Published 10/02/2025, 12:43 PM ET

The NFC West rivalry is back in the spotlight with 49ers vs Rams on Thursday Night Football.

For bettors, divisional matchups like this often deliver prime opportunities to build a sharp same game parlay. With injuries shaping both offenses and two disciplined defenses on the field, this week’s board favors a lower-scoring script and specific player prop angles. Below is a carefully constructed Same Game Parlay for 49ers Rams with three legs designed to maximize value.

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SGP for 49ers vs Rams (+471)

Mac Jones under 216.5 passing yards (-112)
Puka Nacua Under 7.5 receptions (+126)
Under 43.5 (-104)

49ers Rams SGP Leg 1: Mac Jones Under 216.5 Passing Yards

Jones has averaged 281.5 passing yards per game this season, but that came against Arizona and New Orleans. Throughout his carrer, his splits against strong defenses tell a different story.

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The Rams’ pass rush has been more disruptive than preseason expectations suggested, ranking among the top units in pressure rate. With the 49ers also emphasizing time of possession through a balanced attack, Jones is unlikely to air it out consistently. The under on 216.5 passing yards aligns with game flow expectations and defensive matchup trends.

SF/LA SGP Leg 2: Puka Nacua Under 7.5 Receptions

Puka Nacua has become Matthew Stafford’s go-to target. However, this week sets up as a spot to fade his volume. San Francisco’s secondary ranks inside the top-six in coverage metrics and thrives at limiting quick-hit passing windows.

The 49ers vs Rams SGP angle here leans on game script: Los Angeles is expected to run more often to shorten possessions and protect Stafford on a short week. That naturally caps Nacua’s opportunities. Even if he produces efficient yardage, clearing 8 receptions feels unlikely in a game we expect the Rams to play from in front.

TNF Same Game Parlay Leg 3: Under 43.5

Both San Francisco and Los Angeles enter this matchup dealing with offensive injuries that could limit explosive play potential. Pair that with two disciplined defensive fronts, and we lean toward this one staying under 44 points.

San Francisco’s defensive line can dictate tempo, while the Rams prefer a more conservative, ground-based approach when protecting a lead. In divisional games where familiarity often neutralizes big plays, betting the under becomes even stronger.