San Francisco 49ers at Houston Texans Picks and Predictions for Sunday, October 26, 2025

By: David Anicetti Published 10/21/2025, 01:45 PM ET

The San Francisco 49ers face the Houston Texans at NRG Stadium on Sunday, with the opening kickoff at 1:00 PM ET on FOX. San Francisco is 5–2, second in the NFC West, and 3–1 on the road, coming off a 20–10 home win over Atlanta. Houston is 2–4, third in the AFC South, and 1–1 at home, following a 27–19 road loss to Seattle. Scoring the winning touchdown with our NFL picks.

Game Information for 49ers vs Texans

Day/Date: Sunday, October 26

Time: 1:00 PM ET

Where: NRG Stadium, Houston, TX

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TV: FOX

San Francisco 49ers Preview

Mac Jones has thrown for 1,404 yards, six touchdowns, and four interceptions through seven games. Christian McCaffrey leads the team in both rushing and receiving, with 465 rushing yards and 516 receiving yards. San Francisco has won three of its last five games and averages 22 points per game, but the offense has been inconsistent, scoring just 23 total in its two defeats. San Francisco needs strong protection for Jones and steady early-down production to sustain drives.

The defense remains solid but thin due to injuries. Fred Warner (51 tackles) is on injured reserve, and Bryce Huff (4 sacks) is doubtful. Nick Bosa has 2 sacks and continues to draw extra blocking attention. The 49ers allow 17.1 points per game, ranking in the league’s top ten. Without Warner, coverage over the middle has softened, and tackling is a concern.

Houston Texans Preview

C.J. Stroud has thrown for 1,305 yards, nine touchdowns, and four interceptions. Nick Chubb leads with 265 rushing yards, and Nico Collins has 339 yards and three touchdowns, but is questionable with a concussion. Houston has lost two straight after dominant wins over Tennessee and Baltimore earlier in October. The Texans average 21 points per game and are 2–1 when scoring first.

The defense has led the team. Will Anderson Jr. and Danielle Hunter each have four sacks, while safety Jalen Pitre has three interceptions. Azeez Al-Shaair leads with 38 tackles. The Texans have allowed 19.8 points per game over their last four contests and have improved in red-zone coverage. Containing McCaffrey and maintaining consistent pressure on Jones will be central to Houston if the Texans hope to win.

San Francisco 49ers vs. Houston Texans Prediction

Houston has been stronger at home and healthier on defense. Stroud has protected the ball better than Jones, and the Texans’ pass rush matches well against a short-handed San Francisco line. Houston will win at home behind a strong defense that will contain McCaffrey. Final Score Prediction: Houston Texans win and cover ATS 20-17.