San Francisco 49ers at New York Giants Picks and Prediction for Sunday, November 2, 2025

By: David Anicetti Published 11/02/2025, 12:05 AM ET

The San Francisco 49ers visit the New York Giants on Sunday at MetLife Stadium. San Francisco is 5–3 (3–2 away) after a 26–15 loss at Houston. New York is 2–6 (2–1 home) following a 38–20 loss at Philadelphia. San Francisco is second in the NFC West, and New York is fourth in the NFC East. Rush for a winning touchdown using NFL Picks.

Game Information for 49ers vs Giants

Date: Sunday, November 2

Time: 1:00 PM ET

Where: MetLife Stadium, East Rutherford, NJ

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TV: CBS

San Francisco 49ers Preview

San Francisco averages 23.9 points per game and allows 22.3. Mac Jones has thrown for 1,597 yards with eight touchdowns and five interceptions, completing 65.9% of his passes. Christian McCaffrey leads the offense with 490 rushing yards and 559 receiving yards, totaling six touchdowns. Jake Tonges and George Kittle have combined for six receiving scores, while Kendrick Bourne adds 429 yards as a consistent target.

Defensively, linebacker Dee Winters leads the team with 54 tackles, and edge rushers Bryce Huff and Nick Bosa have combined for six sacks. The 49ers have forced a turnover in four straight games but have been vulnerable against the run, allowing 10 rushing touchdowns this year. On the road, San Francisco is 3–2, scoring at least 20 points in every game away from home.

New York Giants Preview

New York averages 21.6 points per game and allows 27.4. Rookie quarterback Jaxson Dart has thrown for 984 yards with eight touchdowns and three interceptions. Running back Cam Skattebo, who leads the team with 410 rushing yards and five touchdowns, is out with an ankle injury. Tyrone Tracy Jr. and Devin Singletary are expected to share carries. Wan’Dale Robinson leads the receivers with 494 yards and two touchdowns.

On defense, linebacker Bobby Okereke leads the team with 68 tackles, and Brian Burns has 10 sacks to lead the pass rush. Cornerback Dru Phillips has two interceptions to lead the secondary. The Giants have won two of three home games but face challenges on offense without Skattebo.

San Francisco 49ers at New York Giants Prediction

San Francisco’s balance on both sides of the ball should be the difference. McCaffrey’s versatility gives the 49ers a reliable source of offense, while the defensive line can pressure Dart into mistakes. The Giants’ defense has been unable to limit big plays, and the offense will miss its most productive runner. Final Score Prediction: San Francisco 49ers win and cover ATS 27-17