San Francisco 49ers vs Seattle Seahawks Picks and Prediction for Sunday September, 7 2025

By: Thomas Pemberton Updated 09/08/2025, 09:04 AM ET

49ers Preview

The San Francisco 49ers head to Seattle to open up their season against the Seahawks. The 49ers won just 6 games last season after they won their division in each of the two seasons before that. The 49ers bring back QB Brock Purdy to run the offense. Prudy threw 20 touchdowns, 12 interceptions, and was sacked 31 times last season. Stay up to date with our expert's NFL Picks.

The San Francisco 49ers went on a four game losing streak to end their season last year. The 49ers will run their offense through RB Christian McCaffrey. McCaffrey played in just 4 games last season. McCaffrey rushed for over 1400 yards in the 2023 season.

Seahawks Preview

The Seattle Seahawks went 10-7 last season. Seattle won six of their last eight games of the season. The Seahawks averaged 22 points scored per game with 21 points against. Seattle brings back head coach Mike Macdonald for his second season.

The Seattle Seahawks have a strong QB room this season. Sam Darnold will be the season started but Jalen Milroe will be chomping at the bit if things don't start well. Seattle hopes that Copper Kupp hopes to make a splash with his new team after not being happy by the release from the Rams. Zach Charbonnet and Kenneth Walker should both see carries in Week 1.

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Seahawks vs 49ers Pick

The Seattle Seahawks are small home underdogs in Week 1. Seattle beat the 49ers by a field goal in their last meeting last season. Grab those free points in what should be a dog fight. Watch for the Seahawks to keep this game close through and pull away late in the game. Final Score Prediction, Seattle Seahawks win and cover ATS 21-20.