Seattle Seahawks vs Arizona Cardinals Picks and Prediction for Thursday September 25 2025

By: Eddie Kline Updated 09/26/2025, 01:00 PM ET

Seahawks Preview

The week four NFL schedule will kick off on Thursday night with a matchup between the Seattle Seahawks and the Arizona Cardinals from State Farm Stadium. Experience the thrill of confident decision-making with our proven methods for selecting top free NFL picks. The Seahawks (2-1) have scored 75 points in their last two games and rank second in the league in scoring defense (15.7 ppg). On Sunday, Tory Horton’s 95-yard punt return touchdown propelled Seattle to a 44-13 home victory versus New Orleans.

Jaxson Smith-Njigba caught a 12-yard touchdown and Kenneth Walker III added a three-yard score as Seattle raced out to a 21-0 first quarter advantage. Sam Darnold connected with Horton on a 14-yard touchdown for the Seahawks, who averaged 5.9 yards per play.

Cardinals Preview

The Arizona Cardinals made a four-win improvement last season and have the talent to contend for a playoff spot this year. The Cardinals (2-1) rank fourth in the league in rushing defense (76.3 ypg) and are allowing 17 points per contest. On Sunday, Arizona surrendered a 35-yard field goal as time expired during a 16-15 road loss against San Francisco.

Arizona managed just two short Chad Ryland field goals through the first three quarters. Kyler Murray found TE Trey McBride for a one-yard touchdown pass to even the score at 13 with eight plus minutes remaining. Marvin Harrison Jr. caught three passes for 44 yards in a losing effort for the Cardinals.

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Seahawks vs Cardinals Pick

Arizona RB James Conner suffered a right ankle injury during Sunday’s loss and will miss the remainder of the season. These two teams have been getting the job done on the defensive side of the ball, so the under is worth a look. The stronger play is on the Seahawks to win on the road. Final Score Prediction, Seattle Seahawks win 24-19.