Tampa Bay Buccaneers at Detroit Lions Picks and Predictions for Monday, October 20, 2025

By: David Anicetti Published 10/20/2025, 12:00 AM ET

The Tampa Bay Buccaneers visit the Detroit Lions at Ford Field on Monday at 7:00 p.m. ET on ABC. Tampa Bay is 5–1 and first in the NFC South after a 30–19 win over San Francisco. Detroit is 4–2, second in the NFC North, following a 30–17 loss at Kansas City. Kick the winning field goal with our NFL predictions.

Tampa Bay Buccaneers Preview

The Buccaneers have won five of six behind quarterback Baker Mayfield, who has thrown for 1,539 yards with 12 touchdowns and one interception. The passing game has been steady, spreading the ball to multiple targets. Emeka Egbuka (questionable) leads with 469 yards and 5 touchdowns, and Sterling Shepard adds 242 yards.

The ground game is shared between Rachaad White and Bucky Irving (questionable), who have combined for 451 yards and 6 touchdowns. The balance has kept defenses honest, and Mayfield has taken advantage of play-action opportunities. Defensively, Tykee Smith leads with 45 tackles, Yaya Diaby has 3 sacks, and Jamel Dean has 2 interceptions. The Buccaneers have held opponents to an average of just 20 points per game and are 3–0 away from home.

Detroit Lions Preview

Jared Goff has been on his game, throwing for 1,390 yards, 14 touchdowns, and 2 interceptions while completing 76% of his passes. Amon-Ra St. Brown continues to be the key weapon with 452 yards and 6 touchdowns, and Sam LaPorta has 324 yards and 2 touchdowns. Jameson Williams adds speed on the perimeter and has scored twice in his last three games.

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The rushing attack is powered by Jahmyr Gibbs with 390 yards and 4 touchdowns, and David Montgomery with 334 yards and 4 touchdowns. On defense, Jack Campbell leads with 56 tackles, Aidan Hutchinson has 6 sacks, and Kerby Joseph has 3 interceptions. Detroit has won both home games by double digits and has scored at least 34 points in each.

Tampa Bay Buccaneers vs Detroit Lions Prediction

Both teams bring balance on offense and active defenses, but Detroit’s passing and rushing games create matchup problems for a Tampa Bay secondary that has given up several long plays. The Buccaneers’ ability to stay in this depends on protecting Mayfield in the pocket and avoiding turnovers. Detroit’s pass protection and red-zone success will be the difference in this matchup. Final Score Prediction: Detroit Lions win and cover ATS 33-23.