Tampa Bay Buccaneers vs Los Angeles Rams Picks and Prediction for Sunday, November 23, 2025

By: Jake Allman Published 11/17/2025, 11:51 PM ET

The Rams enter Week 12 at 8-2 and are riding a five-game winning streak. Los Angeles has handled every challenge lately behind a balanced offense and a defense allowing just 17.2 points per game. Tampa Bay sits at 6-4 and comes in after a tough 44-32 loss at Buffalo that exposed ongoing issues in defense. From underdogs to point spreads, we’ve got the sharpest NFL picks.

Kickoff is scheduled for 8:20 PM ET at SoFi Stadium on NBC. The total is set at 49.5 and the Rams sit -295 on the moneyline. Tampa Bay comes in with several key injuries, including Chris Godwin Jr., Haason Reddick, and Ben Bredeson, all ruled out. Los Angeles lists Tyler Higbee as questionable and is already without Ahkello Witherspoon in the secondary.

Buccaneers Preview

Tampa Bay’s offense averages 25.2 points per game and leans heavily on Baker Mayfield’s 2,365 passing yards and Emeka Egbuka’s 717 receiving yards. The Buccaneers move the ball well through the air at 236.5 passing yards per game, and the run game has been solid with Rachaad White’s 376 yards contributing to 110 rushing yards per game. Tampa Bay has posted a top ten time of possession mark at 31:33, which helps mask a defense that allows 25 points and 342 total yards per game. Recent results give a clear picture with two straight losses, including surrendering 44 to Buffalo and 28 to New England before that. The best sportsbooks are the best way to go when you are betting on the Buccaneers.

Rams Preview

Los Angeles counters with a better attack. Matthew Stafford has thrown for 2,557 yards and continues to drive an offense averaging 27.2 points per game. Puka Nacua already sits at 850 receiving yards, and Kyren Williams’ 750 rushing yards give the Rams a balanced attack averaging 255.7 passing yards and 114 rushing yards per game. The defense has been the difference during this 5 game streak, giving up just 17.2 points and 323 yards per game while generating 27 sacks and holding teams to 100.7 rushing yards. That combination has produced wins over Seattle, San Francisco, New Orleans, Jacksonville, and Baltimore. Make sure you know about how the fans are looking on prediction markets for the Rams with the Onyx Odds promo code.

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Rams vs Buccaneers Prediction

This matchup leans toward Los Angeles because Tampa Bay’s secondary has struggled and now faces a top-10 passing offense. Losing Godwin and Reddick also hurts Tampa Bay on both sides of the ball. The Rams have been more efficient on third downs, stronger in the red zone, and more consistent in closing out games. Tampa Bay needs early stops to keep this close, but recent trends suggest that will be difficult. Getting the most out of your bets on Buccaneers vs Rams can be done by using the Fanatics Sportsbook promo code.

Prediction: Rams 31, Buccaneers 23