Tennessee Titans vs Denver Broncos Picks and Prediction for Sunday September, 7 2025

By: Thomas Pemberton Updated 09/08/2025, 09:04 AM ET

Titans Preview

The Tennessee Titans start their 2025 season on the road with a trip to Denver to take on the Broncos. The Titans haven't won more than 7 games in a season since the 2021 season. Tennessee went 3-14 last season. The Titans will bring back head back Brian Callahan for his second season. Stay up to date with our expert's NFL Picks.

The Tennessee Titans are hoping rookie QB Cam Ward will give them that spark on the offensive side of the ball. The Titans averaged just 18 points scored per game last season while allowing 27 points against. Cam Ward hopes that WR Calvin Ridley will be 100% for this game as he will need that target to get the offense in rhythm. Ward also has Van Jefferson and Tyler Lockett to connect with.

Broncos Preview

The Denver Broncos made it to the Wildcard round last season where they were knocked off by the Buffalo Bills 31-7. Denver went 10-7 in the regular season. The Broncos ranked 3rd best in the NFL allowing just 18 points against per game. Denver hopes to avoid an 0-2 start like they did a year ago.

QB Bo Nix started 17 games for the Denver Broncos last season. Nix threw 29 touchdowns, 12 interceptions, and was sacked 24 times. Denver will feature both Tyler Badie and J.K. Dobbins in the backfield. If the Broncos offense can match their defensive play from last season they should find another playoff spot.

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Broncos vs Titans Pick

The Denver Broncos are a 7.5 favorite heading into Week 1 of the season. The Broncos last played the Titans back in 2022 when they lost by a touchdown. The Broncos have the better roster and head coach heading into this home game. Watch for Denver to grind out a home win. The value lies in the total. Final Score Prediction, Denver Broncos win 17-13 but the play is on the UNDER.