Tennessee Titans vs Indianapolis Colts Picks & Predictions for Sunday, October, 26 2025

By: Thomas Pemberton Published 10/20/2025, 10:37 PM ET

The Tennessee Titans head to Indianapolis for Week 8 to take on the Colts. Kickoff is scheduled for 4:25 PM est at Lucas Oil Stadium. Indianapolis is a -14.5 home favorite and the over/under is set at 47.5 points. Stay up to date with our expert's Free NFL Picks.

Indianapolis Colts Preview

The Indianapolis Colts are an impressive 6-1 on the season and lead the AFC South. The Colts have won three straight games and they carry a perfect 4-0 home field record. Indianapolis is 5-2 against the spread. The Colts beat the Chargers on the road last week 38-24. QB Daniel Jones threw for 288 yards with 2 touchdowns. Jones has 10 touchdowns and 3 interceptions on the season. Indianapolis leads the NFL with 33.1 points scored per game. The Colts have scored over 30 points in three straight games.

Tennessee Titans Preview

The Tennessee Titans are 1-6 on the season and last in the AFC South. The Titans are riding a two game losing streak and they carry a 1-3 road record. Tennessee is 2-5 against the spread. The Titans lost to the Patriots 31-13 in their last game at home. Tennessee has been outscored 51-23 over their last two games. QB Cam Ward had 4 touchdowns with 5 interceptions on the season. Tennessee is averaging 13.7 points scored per game.

Titans vs Colts Picks & Predictions

The Tennessee Titans haven't looked good all season and now are in jeopardy of losing their third straight game. While the Indianapolis Colts have looked like one of the best teams in the NFL and are seeking a fourth straight win. The Colts offensive fire power and the home field advantage will be too much for the Titans to compete with.

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Final Score Prediction: Indianapolis Colts win 31-13 and cover ATS.